2fmd: Difference between revisions

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[[Image:2fmd.gif|left|200px]]
{{Seed}}
[[Image:2fmd.png|left|200px]]


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{{STRUCTURE_2fmd|  PDB=2fmd  |  SCENE=  }}  
{{STRUCTURE_2fmd|  PDB=2fmd  |  SCENE=  }}  


'''Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin'''
===Structural basis of carbohydrate recognition by Bowringia milbraedii seed agglutinin===




==Overview==
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The crystal structure of the seed lectin from the tropical legume Bowringia milbraedii was determined in complex with the disaccharide ligand Man(alpha1-2)Man. In solution, the protein exhibits a dynamic dimer-tetramer equilibrium, consistent with the concanavalin A-type tetramer observed in the crystal. Contacts between the tetramers are mediated almost exclusively through the carbohydrate ligand, resulting in a crystal lattice virtually identical to that of the concanavalin-A:Man(alpha1-2)Man complex, even though both proteins have less than 50% sequence identity. The disaccharide binds exclusively in a "downstream" binding mode, with the non-reducing mannose occupying the monosaccharide-binding site. The reducing mannose is bound in a predominantly polar subsite involving Tyr131, Gln218, and Tyr219.
The line below this paragraph, {{ABSTRACT_PUBMED_16567368}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16567368 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16567368}}


==About this Structure==
==About this Structure==
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[[Category: Legume lectin]]
[[Category: Legume lectin]]
[[Category: Protein-carbohydrate complex]]
[[Category: Protein-carbohydrate complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:04:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:53:00 2008''
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