2fom: Difference between revisions

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[[Image:2fom.gif|left|200px]]
{{Seed}}
[[Image:2fom.png|left|200px]]


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{{STRUCTURE_2fom|  PDB=2fom  |  SCENE=  }}  
{{STRUCTURE_2fom|  PDB=2fom  |  SCENE=  }}  


'''Dengue Virus NS2B/NS3 Protease'''
===Dengue Virus NS2B/NS3 Protease===




==Overview==
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The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
The line below this paragraph, {{ABSTRACT_PUBMED_16532006}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16532006 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16532006}}


==About this Structure==
==About this Structure==
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[[Category: Ns2b cofactor]]
[[Category: Ns2b cofactor]]
[[Category: Ns3 protease]]
[[Category: Ns3 protease]]
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