1prp: Difference between revisions

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[[Image:1prp.jpg|left|200px]]
{{Seed}}
[[Image:1prp.png|left|200px]]


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{{STRUCTURE_1prp|  PDB=1prp  |  SCENE=  }}  
{{STRUCTURE_1prp|  PDB=1prp  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF D(CGCGAATTCGCG) COMPLEXED WITH PROPAMIDINE, A SHORT-CHAIN HOMOLOGUE OF THE DRUG PENTAMIDIN'''
===CRYSTAL STRUCTURE OF D(CGCGAATTCGCG) COMPLEXED WITH PROPAMIDINE, A SHORT-CHAIN HOMOLOGUE OF THE DRUG PENTAMIDIN===




==Overview==
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The crystal structure of the complex between propamidine and the self-complementary DNA dodecamer d(CGCGAATTCGCG) duplex has been determined to a resolution of 2.1 A and a R-factor of 17.4%. The propamidine binds to the DNA within the minor groove, with specific hydrogen-bonding interactions from the amidinium groups to the bases and sugar groups of the DNA, via a 4-base-pair binding site. A network of water molecules lies over the mouth of the minor groove. The structure provides a rationale for the superior DNA-binding properties of propamidine as compared to pentamidine [cf. Edwards, K. J., Jenkins, T. C. &amp; Neidle, S. (1992) Biochemistry 31, 7104-7109]. This is seen to result from (i) decreased minor groove width at the binding site and (ii) reduced mobility of the bound propamidine molecule.
The line below this paragraph, {{ABSTRACT_PUBMED_8268158}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8268158 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8268158}}


==About this Structure==
==About this Structure==
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[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Double helix]]
[[Category: Double helix]]
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