1ytv: Difference between revisions

Line 1:

[[Image:1ytv.~~gif~~|left|200px]]

[[Image:1ytv.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor~~'''~~

===Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor===

~~==Overview==~~

<!--

The V1 vascular vasopressin receptor (V1R) is a G-protein-coupled receptor (GPCR) involved in the regulation of body-fluid osmolality, blood volume and blood pressure. Signal transduction is mediated by the third intracellular loop of this ~~seven-transmembrane protein as well as by the C-terminal cytoplasmic segment. A chimera of the maltose-binding protein (MBP) and the C-terminal segment of V1R has been cloned~~, ~~expressed~~, ~~purified and crystallized. The crystals belong~~ to ~~space group P2~~(~~1), with unit-cell parameters a = 51~~.~~10, b = 66~~.56, ~~c = 115~~.~~72 A, beta = 95.99 degrees. The 1.8 A crystal structure reveals the conformation of MBP and part of the linker region of this chimera, with the C~~-~~terminal segment being unstructured. This may reflect a conformational plasticity in the C~~-~~terminal segment that may be necessary for proper function of V1R.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16511036}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16511036 is the PubMed ID number.

-->

==About this Structure==

Line 35:

Line 39:

[[Category: Receptor]]

[[Category: Vasopressin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 16~~:47:01 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:04:07 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ytv.gif|left|200px]]
+{{Seed}}
+[[Image:1ytv.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ytv|  PDB=1ytv  |  SCENE=  }}
-'''Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor'''
+===Maltose-binding protein fusion to a C-terminal fragment of the V1a vasopressin receptor===
-==Overview==
+<!--
-The V1 vascular vasopressin receptor (V1R) is a G-protein-coupled receptor (GPCR) involved in the regulation of body-fluid osmolality, blood volume and blood pressure. Signal transduction is mediated by the third intracellular loop of this seven-transmembrane protein as well as by the C-terminal cytoplasmic segment. A chimera of the maltose-binding protein (MBP) and the C-terminal segment of V1R has been cloned, expressed, purified and crystallized. The crystals belong to space group P2(1), with unit-cell parameters a = 51.10, b = 66.56, c = 115.72 A, beta = 95.99 degrees. The 1.8 A crystal structure reveals the conformation of MBP and part of the linker region of this chimera, with the C-terminal segment being unstructured. This may reflect a conformational plasticity in the C-terminal segment that may be necessary for proper function of V1R.
+The line below this paragraph, {{ABSTRACT_PUBMED_16511036}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16511036 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16511036}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Receptor]]
 [[Category: Vasopressin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:47:01 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:04:07 2008''