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| {{STRUCTURE_2o5v| PDB=2o5v | SCENE= }} | | {{STRUCTURE_2o5v| PDB=2o5v | SCENE= }} |
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| '''Recombination mediator RecF'''
| | ===Recombination mediator RecF=== |
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| ==Overview==
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| RecF, together with RecO and RecR, belongs to a ubiquitous group of recombination mediators (RMs) that includes eukaryotic proteins such as Rad52 and BRCA2. RMs help maintain genome stability in the presence of DNA damage by loading RecA-like recombinases and displacing single-stranded DNA-binding proteins. Here, we present the crystal structure of RecF from Deinococcus radiodurans. RecF exhibits a high degree of structural similarity with the head domain of Rad50, but lacks its long coiled-coil region. The structural homology between RecF and Rad50 is extensive, encompassing the ATPase subdomain and the so-called 'Lobe II' subdomain of Rad50. The pronounced structural conservation between bacterial RecF and evolutionarily diverged eukaryotic Rad50 implies a conserved mechanism of DNA binding and recognition of the boundaries of double-stranded DNA regions. The RecF structure, mutagenesis of conserved motifs and ATP-dependent dimerization of RecF are discussed with respect to its role in promoting presynaptic complex formation at DNA damage sites.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17255941}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17255941 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17255941}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Signature motif]] | | [[Category: Signature motif]] |
| [[Category: Walker a motif]] | | [[Category: Walker a motif]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 10:22:00 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:25:56 2008'' |
