1son: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1son.jpg|left|200px]]
{{Seed}}
[[Image:1son.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1son|  PDB=1son  |  SCENE=  }}  
{{STRUCTURE_1son|  PDB=1son  |  SCENE=  }}  


'''ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP'''
===ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP===




==Overview==
<!--
(+)-Hydantocidin, a recently discovered natural spironucleoside with potent herbicidal activity, is shown to be a proherbicide that, after phosphorylation at the 5' position, inhibits adenylosuccinate synthetase, an enzyme involved in de novo purine synthesis. The mode of binding of hydantocidin 5'-monophosphate to the target enzyme was analyzed by determining the crystal structure of the enzyme-inhibitor complex at 2.6-A resolution. It was found that adenylosuccinate synthetase binds the phosphorylated compound in the same fashion as it does adenosine 5'-monophosphate, the natural feedback regulator of this enzyme. This work provides the first crystal structure of a herbicide-target complex reported to date.
The line below this paragraph, {{ABSTRACT_PUBMED_8790347}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8790347 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8790347}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Purine nucleotide biosynthesis]]
[[Category: Purine nucleotide biosynthesis]]
[[Category: Synthetase]]
[[Category: Synthetase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 08:57:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:35:36 2008''

Revision as of 10:35, 28 July 2008

File:1son.png

Template:STRUCTURE 1son

ADENYLOSUCCINATE SYNTHETASE IN COMPLEX WITH THE NATURAL FEEDBACK INHIBITOR AMP

Template:ABSTRACT PUBMED 8790347

About this Structure

1SON is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase., Fonne-Pfister R, Chemla P, Ward E, Girardet M, Kreuz KE, Honzatko RB, Fromm HJ, Schar HP, Grutter MG, Cowan-Jacob SW, Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9431-6. PMID:8790347

Page seeded by OCA on Mon Jul 28 13:35:36 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1son&oldid=700821"