1ocn: Difference between revisions

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[[Image:1ocn.jpg|left|200px]]
{{Seed}}
[[Image:1ocn.png|left|200px]]


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{{STRUCTURE_1ocn|  PDB=1ocn  |  SCENE=  }}  
{{STRUCTURE_1ocn|  PDB=1ocn  |  SCENE=  }}  


'''MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION'''
===MUTANT D416A OF THE CELLOBIOHYDROLASE CEL6A FROM HUMICOLA INSOLENS IN COMPLEX WITH A CELLOBIO-DERIVED ISOFAGOMINE AT 1.3 ANGSTROM RESOLUTION===




==Overview==
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A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
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{{ABSTRACT_PUBMED_12744312}}


==About this Structure==
==About this Structure==
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[[Category: Glycoside hydrolase family 6]]
[[Category: Glycoside hydrolase family 6]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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