2gl7: Difference between revisions

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[[Image:2gl7.jpg|left|200px]]
{{Seed}}
[[Image:2gl7.png|left|200px]]


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{{STRUCTURE_2gl7|  PDB=2gl7  |  SCENE=  }}  
{{STRUCTURE_2gl7|  PDB=2gl7  |  SCENE=  }}  


'''Crystal Structure of a beta-catenin/BCL9/Tcf4 complex'''
===Crystal Structure of a beta-catenin/BCL9/Tcf4 complex===




==Overview==
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The canonical Wnt pathway plays critical roles in embryonic development, stem cell growth, and tumorigenesis. Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus, resulting in the transactivation of Wnt target genes. We have determined the crystal structure of a beta-catenin/BCL9/Tcf-4 triple complex at 2.6 A resolution. Our studies reveal that the beta-catenin binding site of BCL9 is distinct from that of most other beta-catenin partners and forms a good target for developing drugs that block canonical Wnt/beta-catenin signaling. The BCL9 beta-catenin binding domain (CBD) forms an alpha helix that binds to the first armadillo repeat of beta-catenin, which can be mutated to prevent beta-catenin binding to BCL9 without affecting cadherin or alpha-catenin binding. We also demonstrate that beta-catenin Y142 phosphorylation, which has been proposed to regulate BCL9-2 binding, does not directly affect the interaction of beta-catenin with either BCL9 or BCL9-2.
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{{ABSTRACT_PUBMED_17052462}}


==About this Structure==
==About this Structure==
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[[Category: Armadillo repeat]]
[[Category: Armadillo repeat]]
[[Category: Protein complex]]
[[Category: Protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:13:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:20:10 2008''

Revision as of 11:20, 28 July 2008

File:2gl7.png

Template:STRUCTURE 2gl7

Crystal Structure of a beta-catenin/BCL9/Tcf4 complex

Template:ABSTRACT PUBMED 17052462

About this Structure

2GL7 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a beta-catenin/BCL9/Tcf4 complex., Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W, Mol Cell. 2006 Oct 20;24(2):293-300. PMID:17052462

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