2c7u: Difference between revisions

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[[Image:2c7u.gif|left|200px]]
{{Seed}}
[[Image:2c7u.png|left|200px]]


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{{STRUCTURE_2c7u|  PDB=2c7u  |  SCENE=  }}  
{{STRUCTURE_2c7u|  PDB=2c7u  |  SCENE=  }}  


'''CONFLICTING SELECTIVE FORCES AFFECT CD8 T-CELL RECEPTOR CONTACT SITES IN AN HLA-A2 IMMUNODOMINANT HIV EPITOPE.'''
===CONFLICTING SELECTIVE FORCES AFFECT CD8 T-CELL RECEPTOR CONTACT SITES IN AN HLA-A2 IMMUNODOMINANT HIV EPITOPE.===




==Overview==
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Cytotoxic T lymphocytes (CTLs) are critical for the control of human immunodeficiency virus, but containment of virus replication can be undermined by mutations in CTL epitopes that lead to virus escape. We analyzed the evolution in vivo of an immunodominant, HLA-A2-restricted CTL epitope and found two principal, diametrically opposed evolutionary pathways that exclusively affect T cell-receptor contact residues. One pathway was characterized by acquisition of CTL escape mutations and the other by selection for wild-type amino acids. The pattern of CTL responses to epitope variants shaped which variant(s) prevailed in the virus population. The pathways notably influenced the amount of plasma virus, as patients with efficient CTL selection had lower plasma viral loads than did patients without efficient selection. Thus, viral escape from CTL responses does not necessarily correlate with disease progression.
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{{ABSTRACT_PUBMED_16388312}}


==About this Structure==
==About this Structure==
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[[Category: Tcr]]
[[Category: Tcr]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:24:05 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:22:42 2008''

Revision as of 11:22, 28 July 2008

File:2c7u.png

Template:STRUCTURE 2c7u

CONFLICTING SELECTIVE FORCES AFFECT CD8 T-CELL RECEPTOR CONTACT SITES IN AN HLA-A2 IMMUNODOMINANT HIV EPITOPE.

Template:ABSTRACT PUBMED 16388312

About this Structure

2C7U is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope., Iversen AK, Stewart-Jones G, Learn GH, Christie N, Sylvester-Hviid C, Armitage AE, Kaul R, Beattie T, Lee JK, Li Y, Chotiyarnwong P, Dong T, Xu X, Luscher MA, MacDonald K, Ullum H, Klarlund-Pedersen B, Skinhoj P, Fugger L, Buus S, Mullins JI, Jones EY, van der Merwe PA, McMichael AJ, Nat Immunol. 2006 Feb;7(2):179-89. Epub 2006 Jan 1. PMID:16388312

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