1mr1: Difference between revisions

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[[Image:1mr1.gif|left|200px]]
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[[Image:1mr1.png|left|200px]]


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{{STRUCTURE_1mr1|  PDB=1mr1  |  SCENE=  }}  
{{STRUCTURE_1mr1|  PDB=1mr1  |  SCENE=  }}  


'''Crystal Structure of a Smad4-Ski Complex'''
===Crystal Structure of a Smad4-Ski Complex===




==Overview==
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The Ski family of nuclear oncoproteins represses TGF-beta signaling through interactions with the Smad proteins. The crystal structure of the Smad4 binding domain of human c-Ski in complex with the MH2 domain of Smad4 reveals specific recognition of the Smad4 L3 loop region by a highly conserved interaction loop (I loop) from Ski. The Ski binding surface on Smad4 significantly overlaps with that required for binding of the R-Smads. Indeed, Ski disrupts the formation of a functional complex between the Co- and R-Smads, explaining how it could lead to repression of TGF-beta, activin, and BMP responses. Intriguingly, the structure of the Ski fragment, stabilized by a bound zinc atom, resembles the SAND domain, in which the corresponding I loop is responsible for DNA binding.
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{{ABSTRACT_PUBMED_12419246}}


==About this Structure==
==About this Structure==
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[[Category: Smad]]
[[Category: Smad]]
[[Category: Tgf-b signaling]]
[[Category: Tgf-b signaling]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:37:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:37:18 2008''

Revision as of 11:37, 28 July 2008

File:1mr1.png

Template:STRUCTURE 1mr1

Crystal Structure of a Smad4-Ski Complex

Template:ABSTRACT PUBMED 12419246

About this Structure

1MR1 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: insights on Ski-mediated repression of TGF-beta signaling., Wu JW, Krawitz AR, Chai J, Li W, Zhang F, Luo K, Shi Y, Cell. 2002 Nov 1;111(3):357-67. PMID:12419246

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