1q47: Difference between revisions

Line 1:

[[Image:1q47.~~gif~~|left|200px]]

[[Image:1q47.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Structure of the Semaphorin 3A Receptor-Binding Module~~'''~~

===Structure of the Semaphorin 3A Receptor-Binding Module===

~~==Overview==~~

<!--

The ~~semaphorins are a large group of extracellular proteins involved in a variety of processes during development~~, ~~including neuronal migration and axon guidance. Their distinctive feature is a conserved 500 amino acid semaphorin domain~~, ~~a ligand-receptor interaction module also present in plexins and scatter-factor receptors. We report~~ the ~~crystal structure of a secreted 65 kDa form of Semaphorin-3A~~ (~~Sema3A~~), ~~containing the full semaphorin domain. Unexpectedly, the semaphorin fold~~ is ~~a variation of~~ the ~~beta propeller topology~~. ~~Analysis of the Sema3A structure and structure~~-based mutagenesis data identify the neuropilin binding site and suggest a potential plexin interaction site. Based on the structure, we present a model for the initiation of semaphorin signaling and discuss potential similarities with the signaling mechanisms of other beta propeller cell surface receptors, such as integrins and the LDL receptor.

The line below this paragraph, {{ABSTRACT_PUBMED_12925274}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12925274 is the PubMed ID number.

-->

==About this Structure==

Line 34:

Line 38:

[[Category: Rajashankar, K R.]]

[[Category: Beta propeller]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:50:58 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:38:58 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1q47.gif|left|200px]]
+{{Seed}}
+[[Image:1q47.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1q47|  PDB=1q47  |  SCENE=  }}
-'''Structure of the Semaphorin 3A Receptor-Binding Module'''
+===Structure of the Semaphorin 3A Receptor-Binding Module===
-==Overview==
+<!--
-The semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance. Their distinctive feature is a conserved 500 amino acid semaphorin domain, a ligand-receptor interaction module also present in plexins and scatter-factor receptors. We report the crystal structure of a secreted 65 kDa form of Semaphorin-3A (Sema3A), containing the full semaphorin domain. Unexpectedly, the semaphorin fold is a variation of the beta propeller topology. Analysis of the Sema3A structure and structure-based mutagenesis data identify the neuropilin binding site and suggest a potential plexin interaction site. Based on the structure, we present a model for the initiation of semaphorin signaling and discuss potential similarities with the signaling mechanisms of other beta propeller cell surface receptors, such as integrins and the LDL receptor.
+The line below this paragraph, {{ABSTRACT_PUBMED_12925274}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12925274 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12925274}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Rajashankar, K R.]]
 [[Category: Beta propeller]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:50:58 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:38:58 2008''