1v3n: Difference between revisions

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[[Image:1v3n.gif|left|200px]]
{{Seed}}
[[Image:1v3n.png|left|200px]]


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'''Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex'''
===Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex===




==Overview==
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Recent genomic analyses revealed many kinds of tandem repeats of specific sequences. Some of them are related to genetic diseases, but their biological functions and structures are still unknown. Two X-ray structures of a short DNA fragment d(gcGA[G]1Agc) show that four base-intercalated duplexes are assembled to form an octaplex at a low K+ concentration, in which the eight G5 residues form a stacked double G-quartet in the central part. At a higher K+ concentration, however, the octaplex is split into just two halves. These structural features suggest a folding process of eight tandem repeats of d(ccGA[G]4Agg), according to a double Greek-key motif. Such a packaging of the repeats could facilitate slippage of a certain sequence during DNA replication, to induce increase or decrease of the repeats.
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{{ABSTRACT_PUBMED_15133122}}


==About this Structure==
==About this Structure==
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[[Category: Sheared g:a pair]]
[[Category: Sheared g:a pair]]
[[Category: X-ray analysis]]
[[Category: X-ray analysis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:02:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:47:28 2008''

Revision as of 11:47, 28 July 2008

File:1v3n.png

Template:STRUCTURE 1v3n

Crystal structure of d(GCGAGAGC): the DNA quadruplex structure split from the octaplex

Template:ABSTRACT PUBMED 15133122

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structures of a DNA octaplex with I-motif of G-quartets and its splitting into two quadruplexes suggest a folding mechanism of eight tandem repeats., Kondo J, Adachi W, Umeda S, Sunami T, Takenaka A, Nucleic Acids Res. 2004 May 7;32(8):2541-9. Print 2004. PMID:15133122

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