1vmp: Difference between revisions

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[[Image:1vmp.jpg|left|200px]]
{{Seed}}
[[Image:1vmp.png|left|200px]]


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{{STRUCTURE_1vmp|  PDB=1vmp  |  SCENE=  }}  
{{STRUCTURE_1vmp|  PDB=1vmp  |  SCENE=  }}  


'''STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II'''
===STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II===




==Overview==
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We report the solution structure of the chemotactic cytokine (chemokine) vMIP-II. This protein has unique biological activities in that it blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors, some of which are used by HJV to gain cell entry. vMIP-II is a monomeric protein, unlike most members of the chemokine family, and its structure consists of a disordered N-terminus, followed by a helical turn (Gln25-Leu27), which leads into the first strand of a three-stranded antiparallel beta-sheet (Ser29-Thr34; Gly42-Thr47; Gln52-Asp56). Following the sheet is a C-terminal alpha-helix, which extends from residue Asp60 until Gln68. The final five residues beyond the C-terminal helix (Pro70-Arg74) are in an extended conformation, but several of these C-terminal residues contact the first beta-strand. The structure of vMIP-II is compared to other chemokines that also block infection by HIV-1, and the structural basis of its lack of ability to form a dimer is discussed.
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{{ABSTRACT_PUBMED_10595530}}


==About this Structure==
==About this Structure==
1VMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA].  
1VMP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMP OCA].  


==Reference==
==Reference==
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[[Category: Sarcoma]]
[[Category: Sarcoma]]
[[Category: Vmip-ii]]
[[Category: Vmip-ii]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:43:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:54:48 2008''

Revision as of 11:54, 28 July 2008

File:1vmp.png

Template:STRUCTURE 1vmp

STRUCTURE OF THE ANTI-HIV CHEMOKINE VMIP-II

Template:ABSTRACT PUBMED 10595530

About this Structure

1VMP is a Single protein structure of sequence from Human herpesvirus 8. Full experimental information is available from OCA.

Reference

The solution structure of the anti-HIV chemokine vMIP-II., Liwang AC, Wang ZX, Sun Y, Peiper SC, Liwang PJ, Protein Sci. 1999 Nov;8(11):2270-80. PMID:10595530

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