1y16: Difference between revisions

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[[Image:1y16.gif|left|200px]]
{{Seed}}
[[Image:1y16.png|left|200px]]


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{{STRUCTURE_1y16|  PDB=1y16  |  SCENE=  }}  
{{STRUCTURE_1y16|  PDB=1y16  |  SCENE=  }}  


'''mouse prion protein with mutations S170N and N174T'''
===mouse prion protein with mutations S170N and N174T===




==Overview==
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The NMR structure of the recombinant elk prion protein (ePrP), which represents the cellular isoform (ePrPC) in the healthy organism, is described here. As anticipated from the highly conserved amino acid sequence, ePrPC has the same global fold as other mammalian prion proteins (PrPs), with a flexibly disordered "tail" of residues 23-124 and a globular domain 125-226 with three alpha-helices and a short antiparallel beta-sheet. However, ePrPC shows a striking local structure variation when compared with most other mammalian PrPs, in particular human, bovine, and mouse PrPC. A loop of residues 166-175, which links the beta-sheet with the alpha2-helix and is part of a hypothetical "protein X" epitope, is outstandingly well defined, whereas this loop is disordered in the other species. Based on NMR structure determinations of two mouse PrP variants, mPrP[N174T] and mPrP[S170N,N174T], this study shows that the structured loop in ePrPC relates to these two local amino acid exchanges, so that mPrP[S170N,N174T] exactly mimics ePrPC. These results are evaluated in the context of recent reports on chronic wasting disease (CWD) in captive and free-ranging deer and elk in the U.S. and Canada, and an animal model is proposed for support of future research on CWD.
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{{ABSTRACT_PUBMED_15647363}}


==About this Structure==
==About this Structure==
1Y16 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y16 OCA].  
1Y16 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y16 OCA].  


==Reference==
==Reference==
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[[Category: Prp]]
[[Category: Prp]]
[[Category: Tse]]
[[Category: Tse]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:45:35 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:06:48 2008''

Revision as of 12:06, 28 July 2008

File:1y16.png

Template:STRUCTURE 1y16

mouse prion protein with mutations S170N and N174T

Template:ABSTRACT PUBMED 15647363

About this Structure

1Y16 is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Prion protein NMR structures of elk and of mouse/elk hybrids., Gossert AD, Bonjour S, Lysek DA, Fiorito F, Wuthrich K, Proc Natl Acad Sci U S A. 2005 Jan 18;102(3):646-50. Epub 2005 Jan 12. PMID:15647363

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