2qtb: Difference between revisions

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[[Image:2qtb.~~jpg~~|left|200px]]

[[Image:2qtb.png|left|200px]]

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~~'''~~Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor~~'''~~

===Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor===

~~==Overview==~~

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~~A novel series of 4~~-~~arylcyclohexylalanine DPP~~-~~4 inhibitors was synthesized and tested for inhibitory activity as well as selectivity over~~ the ~~related proline-specific enzymes DPP-8 and DPP-9. Optimization of this series led~~ to 28 (~~DPP-4 IC(50)=4~~.~~8 nM~~), which showed an excellent pharmacokinetic profile across several preclinical species. Evaluation of 28 in an oral glucose tolerance test demonstrated that this compound effectively reduced glucose excursion in lean mice.

The line below this paragraph, {{ABSTRACT_PUBMED_17851076}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17851076 is the PubMed ID number.

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==About this Structure==

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[[Category: Signal-anchor]]

[[Category: Transmembrane]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 15:38:41 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:07:08 2008''

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-[[Image:2qtb.jpg|left|200px]]
+{{Seed}}
+[[Image:2qtb.png|left|200px]]
 <!--
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 {{STRUCTURE_2qtb|  PDB=2qtb  |  SCENE=  }}
-'''Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor'''
+===Human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl cyclohexylalanine inhibitor===
-==Overview==
+<!--
-A novel series of 4-arylcyclohexylalanine DPP-4 inhibitors was synthesized and tested for inhibitory activity as well as selectivity over the related proline-specific enzymes DPP-8 and DPP-9. Optimization of this series led to 28 (DPP-4 IC(50)=4.8 nM), which showed an excellent pharmacokinetic profile across several preclinical species. Evaluation of 28 in an oral glucose tolerance test demonstrated that this compound effectively reduced glucose excursion in lean mice.
+The line below this paragraph, {{ABSTRACT_PUBMED_17851076}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17851076 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17851076}}
 ==About this Structure==
@@ Line 36: / Line 40: @@
 [[Category: Signal-anchor]]
 [[Category: Transmembrane]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 15:38:41 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:07:08 2008''