264d: Difference between revisions

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[[Image:264d.jpg|left|200px]]
{{Seed}}
[[Image:264d.png|left|200px]]


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{{STRUCTURE_264d|  PDB=264d  |  SCENE=  }}  
{{STRUCTURE_264d|  PDB=264d  |  SCENE=  }}  


'''THREE-DIMENSIONAL CRYSTAL STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR-GROOVE-BINDING DRUG HOECHST 33258'''
===THREE-DIMENSIONAL CRYSTAL STRUCTURE OF THE A-TRACT DNA DODECAMER D(CGCAAATTTGCG) COMPLEXED WITH THE MINOR-GROOVE-BINDING DRUG HOECHST 33258===




==Overview==
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The molecular structure of the DNA A-tract dodecamer d(CGCAAATTTGCG) complexed with the drug Hoechst 33258 has been determined by X-ray diffraction analysis. The Hoechst molecule binds in the DNA minor groove covering the sequence AATTT of the central A-tract, with the piperazine group close to one of the GC regions. The drug molecule makes two three-centered hydrogen bonds from the nitrogen atoms of the benzimidazole rings to the N3 and O2 atoms of the DNA bases. Although a high propeller twist is observed in the A-tract, only one unsymmetrical three-centered hydrogen bond is present in the DNA major groove. The structure is compared with other minor-groove-binding drug complexes and the influence of these drugs on DNA A-tracts is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_7517864}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7517864 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7517864}}


==About this Structure==
==About this Structure==
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[[Category: Complexed with drug]]
[[Category: Complexed with drug]]
[[Category: Double helix]]
[[Category: Double helix]]
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