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| {{STRUCTURE_2hbn| PDB=2hbn | SCENE= }} | | {{STRUCTURE_2hbn| PDB=2hbn | SCENE= }} |
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| '''Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex'''
| | ===Crystallization of the Tl+-form of the Oxytricha nova G-quadruplex=== |
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| ==Overview==
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| The crystal structure of the Tl+ form of the G-quadruplex formed from the Oxytricha nova telomere sequence, d(G4T4G4), has been solved to 1.55 A. This G-quadruplex contains five Tl+ ions, three of which are interspersed between adjacent G-quartet planes and one in each of the two thymine loops. The structure displays a high degree of similarity to the K+ crystal structure [Haider et al. (2002), J. Mol. Biol., 320, 189-200], including the number and location of the monovalent cation binding sites. The highly isomorphic nature of the two structures, which contain such a large number of monovalent binding sites (relative to nucleic acid content), verifies the ability of Tl+ to mimic K+ in nucleic acids. Information from this report confirms and extends the assignment of 205Tl resonances from a previous report [Gill et al. (2005), J. Am. Chem. Soc., 127, 16 723-16 732] where 205Tl NMR was used to study monovalent cation binding to this G-quadruplex. The assignment of these resonances provides evidence for the occurrence of conformational dynamics in the thymine loop region that is in slow exchange on the 205Tl timescale. | | The line below this paragraph, {{ABSTRACT_PUBMED_16945956}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16945956 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16945956}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: G-quadruplex]] | | [[Category: G-quadruplex]] |
| [[Category: Thallium]] | | [[Category: Thallium]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:05:44 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:32:04 2008'' |
