1n9a: Difference between revisions

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[[Image:1n9a.gif|left|200px]]
{{Seed}}
[[Image:1n9a.png|left|200px]]


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{{STRUCTURE_1n9a|  PDB=1n9a  |  SCENE=  }}  
{{STRUCTURE_1n9a|  PDB=1n9a  |  SCENE=  }}  


'''Farnesyltransferase complex with tetrahydropyridine inhibitors'''
===Farnesyltransferase complex with tetrahydropyridine inhibitors===




==Overview==
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Inhibitors of farnesyltransferase are effective against a variety of tumors in mouse models of cancer. Clinical trials to evaluate these agents in humans are ongoing. In our effort to develop new farnesyltransferase inhibitors, we have discovered bioavailable aryl tetrahydropyridines that are potent in cell culture. The design, synthesis, SAR and biological properties of these compounds will be discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_12657283}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12657283 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12657283}}


==About this Structure==
==About this Structure==
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[[Category: Prenyltransferase]]
[[Category: Prenyltransferase]]
[[Category: Tetrahydropyridine]]
[[Category: Tetrahydropyridine]]
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