2trt: Difference between revisions

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[[Image:2trt.gif|left|200px]]
{{Seed}}
[[Image:2trt.png|left|200px]]


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{{STRUCTURE_2trt|  PDB=2trt  |  SCENE=  }}  
{{STRUCTURE_2trt|  PDB=2trt  |  SCENE=  }}  


'''TETRACYCLINE REPRESSOR CLASS D'''
===TETRACYCLINE REPRESSOR CLASS D===




==Overview==
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The most frequently occurring resistance of Gram-negative bacteria against tetracyclines is triggered by drug recognition of the Tet repressor. This causes dissociation of the repressor-operator DNA complex and enables expression of the resistance protein TetA, which is responsible for active efflux of tetracycline. The 2.5 angstrom resolution crystal structure of the homodimeric Tet repressor complexed with tetracycline-magnesium reveals detailed drug recognition. The orientation of the operator-binding helix-turn-helix motifs of the repressor is inverted in comparison with other DNA binding proteins. The repressor-drug complex is unable to interact with DNA because the separation of the DNA binding motifs is 5 angstroms wider than usually observed.
The line below this paragraph, {{ABSTRACT_PUBMED_8153629}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8153629 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8153629}}


==About this Structure==
==About this Structure==
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[[Category: Repressor]]
[[Category: Repressor]]
[[Category: Transcription regulation]]
[[Category: Transcription regulation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 17:26:41 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:35:36 2008''
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