1uak: Difference between revisions

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[[Image:1uak.gif|left|200px]]
{{Seed}}
[[Image:1uak.png|left|200px]]


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{{STRUCTURE_1uak|  PDB=1uak  |  SCENE=  }}  
{{STRUCTURE_1uak|  PDB=1uak  |  SCENE=  }}  


'''Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition'''
===Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition===




==Overview==
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tRNA(m(1)G37)methyltransferase (TrmD) catalyzes the transfer of a methyl group from S-adenosyl-L- methionine (AdoMet) to G(37) within a subset of bacterial tRNA species, which have a G residue at the 36th position. The modified guanosine is adjacent to and 3' of the anticodon and is essential for the maintenance of the correct reading frame during translation. Here we report four crystal structures of TrmD from Haemophilus influenzae, as binary complexes with either AdoMet or S-adenosyl-L-homocysteine (AdoHcy), as a ternary complex with AdoHcy and phosphate, and as an apo form. This first structure of TrmD indicates that it functions as a dimer. It also suggests the binding mode of G(36)G(37) in the active site of TrmD and the catalytic mechanism. The N-terminal domain has a trefoil knot, in which AdoMet or AdoHcy is bound in a novel, bent conformation. The C-terminal domain shows structural similarity to trp repressor. We propose a plausible model for the TrmD(2)-tRNA(2) complex, which provides insights into recognition of the general tRNA structure by TrmD.
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{{ABSTRACT_PUBMED_12773376}}


==About this Structure==
==About this Structure==
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[[Category: Trmd]]
[[Category: Trmd]]
[[Category: Trna modification]]
[[Category: Trna modification]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 10:58:11 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:35:56 2008''

Revision as of 12:35, 28 July 2008

File:1uak.png

Template:STRUCTURE 1uak

Crystal structure of tRNA(m1G37)methyltransferase: Insight into tRNA recognition

Template:ABSTRACT PUBMED 12773376

About this Structure

1UAK is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition., Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK, EMBO J. 2003 Jun 2;22(11):2593-603. PMID:12773376

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