1sb3: Difference between revisions

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[[Image:1sb3.gif|left|200px]]
{{Seed}}
[[Image:1sb3.png|left|200px]]


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{{STRUCTURE_1sb3|  PDB=1sb3  |  SCENE=  }}  
{{STRUCTURE_1sb3|  PDB=1sb3  |  SCENE=  }}  


'''Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica'''
===Structure of 4-hydroxybenzoyl-CoA reductase from Thauera aromatica===




==Overview==
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The Mo-flavo-Fe/S-dependent heterohexameric protein complex 4-hydroxybenzoyl-CoA reductase (4-HBCR, dehydroxylating) is a central enzyme of the anaerobic degradation of phenolic compounds and belongs to the xanthine oxidase (XO) family of molybdenum enzymes. Its X-ray structure was established at 1.6 A resolution. The most pronounced difference between 4-HBCR and other structurally characterized members of the XO family is the insertion of 40 amino acids within the beta subunit, which carries an additional [4Fe-4S] cluster at a distance of 16.5 A to the isoalloxazine ring of FAD. The architecture of 4-HBCR and concomitantly performed electron transfer rate calculations suggest an inverted electron transfer chain from the donor ferredoxin via the [4Fe-4S] cluster to the Mo over a distance of 55 A. The binding site of 4-hydroxybenzoyl-CoA is located in an 18 A long channel lined up by several aromatic side chains around the aromatic moiety, which are proposed to shield and stabilize the postulated radical intermediates during catalysis.
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{{ABSTRACT_PUBMED_15576037}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of a xanthine oxidase-related 4-hydroxybenzoyl-CoA reductase with an additional [4Fe-4S] cluster and an inverted electron flow., Unciuleac M, Warkentin E, Page CC, Boll M, Ermler U, Structure. 2004 Dec;12(12):2249-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576037 15576037]
Structure of a xanthine oxidase-related 4-hydroxybenzoyl-CoA reductase with an additional [4Fe-4S] cluster and an inverted electron flow., Unciuleac M, Warkentin E, Page CC, Boll M, Ermler U, Structure. 2004 Dec;12(12):2249-56. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15576037 15576037]
Crystallization of 4-hydroxybenzoyl-CoA reductase and the structure of its electron donor ferredoxin., Unciuleac M, Boll M, Warkentin E, Ermler U, Acta Crystallogr D Biol Crystallogr. 2004 Feb;60(Pt 2):388-91. Epub 2004, Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14747735 14747735]
[[Category: 4-hydroxybenzoyl-CoA reductase]]
[[Category: 4-hydroxybenzoyl-CoA reductase]]
[[Category: Protein complex]]
[[Category: Protein complex]]
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[[Category: Dimer of heterotrimer]]
[[Category: Dimer of heterotrimer]]
[[Category: Xanthine oxidase family]]
[[Category: Xanthine oxidase family]]
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