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| {{STRUCTURE_2ol3| PDB=2ol3 | SCENE= }} | | {{STRUCTURE_2ol3| PDB=2ol3 | SCENE= }} |
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| '''crystal structure of BM3.3 ScFV TCR in complex with PBM8-H-2KBM8 MHC class I molecule'''
| | ===crystal structure of BM3.3 ScFV TCR in complex with PBM8-H-2KBM8 MHC class I molecule=== |
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| ==Overview==
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| Binding degeneracy is thought to constitute a fundamental property of the T-cell antigen receptor (TCR), yet its structural basis is poorly understood. We determined the crystal structure of a complex involving the BM3.3 TCR and a peptide (pBM8) bound to the H-2K(bm8) major histocompatibility complex (MHC) molecule, and compared it with the structures of the BM3.3 TCR bound to H-2K(b) molecules loaded with two peptides that had a minimal level of primary sequence identity with pBM8. Our findings provide a refined structural view of the basis of BM3.3 TCR cross-reactivity and a structural explanation for the long-standing paradox that a TCR antigen-binding site can be both specific and degenerate. We also measured the thermodynamic features and biological penalties that incurred during cross-recognition. Our data illustrate the difficulty for a given TCR in adapting to distinct peptide-MHC surfaces while still maintaining affinities that result in functional in vivo responses. Therefore, when induction of protective effector T cells is used as the ultimate criteria for adaptive immunity, TCRs are probably much less degenerate than initially assumed.
| | The line below this paragraph, {{ABSTRACT_PUBMED_17363906}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17363906 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17363906}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: T cell receptor]] | | [[Category: T cell receptor]] |
| [[Category: Tcr-pmhc complex]] | | [[Category: Tcr-pmhc complex]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:08:24 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:38:08 2008'' |
