2a2f: Difference between revisions

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[[Image:2a2f.png|left|200px]]

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~~'''~~Crystal Structure of Sec15 C-terminal domain~~'''~~

===Crystal Structure of Sec15 C-terminal domain===

~~==Overview==~~

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~~Sec15~~, ~~a component of~~ the ~~exocyst, recognizes vesicle-associated Rab GTPases, helps target transport vesicles~~ to the ~~budding sites in yeast and is thought to recruit other exocyst proteins~~. ~~Here we report the characterization of a 35-kDa fragment that comprises most of the C-terminal half of Drosophila melanogaster Sec15~~. ~~This C-terminal domain was found to bind a subset of Rab GTPases~~, ~~especially Rab11, in a GTP-dependent manner. We also provide evidence that in fly photoreceptors Sec15 colocalizes with Rab11 and that loss of Sec15 affects rhabdomere morphology. Determination of~~ the 2.~~5-A crystal structure of the C~~-~~terminal domain revealed a novel fold consisting of ten alpha~~-~~helices equally distributed between two subdomains (N and C subdomains). We show that the C subdomain, mainly via a single helix, is sufficient for Rab binding.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16155582}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16155582 is the PubMed ID number.

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==About this Structure==

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[[Category: Wu, S.]]

[[Category: All helical structure]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:31:03 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:42:11 2008''

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-[[Image:2a2f.gif|left|200px]]
+{{Seed}}
+[[Image:2a2f.png|left|200px]]
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 {{STRUCTURE_2a2f|  PDB=2a2f  |  SCENE=  }}
-'''Crystal Structure of Sec15 C-terminal domain'''
+===Crystal Structure of Sec15 C-terminal domain===
-==Overview==
+<!--
-Sec15, a component of the exocyst, recognizes vesicle-associated Rab GTPases, helps target transport vesicles to the budding sites in yeast and is thought to recruit other exocyst proteins. Here we report the characterization of a 35-kDa fragment that comprises most of the C-terminal half of Drosophila melanogaster Sec15. This C-terminal domain was found to bind a subset of Rab GTPases, especially Rab11, in a GTP-dependent manner. We also provide evidence that in fly photoreceptors Sec15 colocalizes with Rab11 and that loss of Sec15 affects rhabdomere morphology. Determination of the 2.5-A crystal structure of the C-terminal domain revealed a novel fold consisting of ten alpha-helices equally distributed between two subdomains (N and C subdomains). We show that the C subdomain, mainly via a single helix, is sufficient for Rab binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_16155582}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16155582 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16155582}}
 ==About this Structure==
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 [[Category: Wu, S.]]
 [[Category: All helical structure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:31:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:42:11 2008''