2nuo: Difference between revisions

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[[Image:2nuo.jpg|left|200px]]
{{Seed}}
[[Image:2nuo.png|left|200px]]


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{{STRUCTURE_2nuo|  PDB=2nuo  |  SCENE=  }}  
{{STRUCTURE_2nuo|  PDB=2nuo  |  SCENE=  }}  


'''Crystal structure of a complex of griffithsin with glucose'''
===Crystal structure of a complex of griffithsin with glucose===




==Overview==
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Crystal structures of complexes of an antiviral lectin griffithsin (GRFT) with glucose and N-acetylglucosamine were solved and refined at high resolution. In both complexes, all six monosaccharide-binding sites of GRFT were occupied and the mode of binding was similar to that of mannose. In our previous attempts to obtain a complex with N-acetylglucosamine by soaking, only a single site was occupied; thus, cocrystallization was clearly superior despite lower concentration of the ligand. Isothermal titration calorimetric experiments with N-acetylglucosamine, glucose, and mannose provided enthalpic evidence of distinct binding differences between the three monosaccharides. A comparison of the mode of binding of different monosaccharides is discussed in the context of the antiviral activity of GRFT, based on specific binding to high-mannose-containing complex carbohydrates found on viral envelopes.
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{{ABSTRACT_PUBMED_17567736}}


==About this Structure==
==About this Structure==
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[[Category: Sar]]
[[Category: Sar]]
[[Category: Sugar binding protein]]
[[Category: Sugar binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:59:38 2008''

Revision as of 12:59, 28 July 2008

File:2nuo.png

Template:STRUCTURE 2nuo

Crystal structure of a complex of griffithsin with glucose

Template:ABSTRACT PUBMED 17567736

About this Structure

2NUO is a Single protein structure of sequence from Griffithsia. Full crystallographic information is available from OCA.

Reference

Crystallographic studies of the complexes of antiviral protein griffithsin with glucose and N-acetylglucosamine., Ziolkowska NE, Shenoy SR, O'Keefe BR, Wlodawer A, Protein Sci. 2007 Jul;16(7):1485-9. Epub 2007 Jun 13. PMID:17567736

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