1xhp: Difference between revisions

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[[Image:1xhp.gif|left|200px]]
{{Seed}}
[[Image:1xhp.png|left|200px]]


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{{STRUCTURE_1xhp|  PDB=1xhp  |  SCENE=  }}  
{{STRUCTURE_1xhp|  PDB=1xhp  |  SCENE=  }}  


'''Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae'''
===Solution Structure of the Extended U6 ISL as Observed in the U2/U6 complex from Saccharomyces cerevisiae===




==Overview==
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Intron removal in nuclear precursor mRNA is catalyzed through two transesterification reactions by a multi-megaDalton ribonucleoprotein machine called the spliceosome. A complex between U2 and U6 small nuclear RNAs is a core component of the spliceosome. Here we present an NMR structural analysis of a protein-free U2-U6 complex from Saccharomyces cerevisiae. The observed folding of the U2-U6 complex is a four-helix junction, in which the catalytically important AGC triad base-pairs only within U6 and not with U2. The base-pairing of the AGC triad extends the U6 intramolecular stem-loop (U6 ISL), and the NMR structure of this extended U6 ISL reveals structural similarities with domain 5 of group II self-splicing introns. The observed conformation of the four-helix junction could be relevant to the first, but not the second, step of splicing and may help to position the U6 ISL adjacent to the 5' splice site.
The line below this paragraph, {{ABSTRACT_PUBMED_15543154}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15543154 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15543154}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XHP OCA].  


==Reference==
==Reference==
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[[Category: Rna stem-loop]]
[[Category: Rna stem-loop]]
[[Category: U6 rna]]
[[Category: U6 rna]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:02:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:04:23 2008''
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