2acl: Difference between revisions

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[[Image:2acl.gif|left|200px]]
{{Seed}}
[[Image:2acl.png|left|200px]]


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{{STRUCTURE_2acl|  PDB=2acl  |  SCENE=  }}  
{{STRUCTURE_2acl|  PDB=2acl  |  SCENE=  }}  


'''Liver X-Receptor alpha Ligand Binding Domain with SB313987'''
===Liver X-Receptor alpha Ligand Binding Domain with SB313987===




==Overview==
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Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression. Mechanism of action studies led to the identification of GSK3987 as an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC(50)s of 40 nM, profiles as an LXR agonist in functional assays, and activates LXR though a mechanism that is similar to first generation LXR agonists.
The line below this paragraph, {{ABSTRACT_PUBMED_16107141}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16107141 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16107141}}


==About this Structure==
==About this Structure==
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[[Category: Smallwood, A.]]
[[Category: Smallwood, A.]]
[[Category: Nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold]]
[[Category: Nuclear hormone receptor ligand binding domain transcription factor three layered a-helix fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:52:53 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:07:01 2008''
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