1qpx: Difference between revisions

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[[Image:1qpx.jpg|left|200px]]
{{Seed}}
[[Image:1qpx.png|left|200px]]


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{{STRUCTURE_1qpx|  PDB=1qpx  |  SCENE=  }}  
{{STRUCTURE_1qpx|  PDB=1qpx  |  SCENE=  }}  


'''CRYSTAL STRUCTURES OF SELF-CAPPING PAPD CHAPERONE HOMODIMERS'''
===CRYSTAL STRUCTURES OF SELF-CAPPING PAPD CHAPERONE HOMODIMERS===




==Overview==
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PapD is an immunoglobulin-like chaperone that mediates the assembly of P pili in uropathogenic strains of Escherichia coli. It binds and caps interactive surfaces on pilus subunits to prevent their premature associations in the periplasm. We elucidated the structural basis of a mechanism whereby PapD also interacts with itself, capping its own subunit binding surface. Crystal structures of dimeric forms of PapD revealed that this self-capping mechanism involves a rearrangement and ordering of the C2-D2 and F1-G1 loops upon dimerization which might ensure that a stable dimer is not formed in solution in spite of a relatively large dimer interface. An analysis of site directed mutations revealed that chaperone dimerization requires the same surface that is otherwise used to bind subunits.
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{{ABSTRACT_PUBMED_10393968}}


==About this Structure==
==About this Structure==
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[[Category: Chaperone]]
[[Category: Chaperone]]
[[Category: Immunoglobulin fold]]
[[Category: Immunoglobulin fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:34:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:07:20 2008''

Revision as of 13:07, 28 July 2008

File:1qpx.png

Template:STRUCTURE 1qpx

CRYSTAL STRUCTURES OF SELF-CAPPING PAPD CHAPERONE HOMODIMERS

Template:ABSTRACT PUBMED 10393968

About this Structure

1QPX is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis of chaperone self-capping in P pilus biogenesis., Hung DL, Pinkner JS, Knight SD, Hultgren SJ, Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8178-83. PMID:10393968

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