1qfp: Difference between revisions

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[[Image:1qfp.~~gif~~|left|200px]]

[[Image:1qfp.png|left|200px]]

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~~'''~~N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)~~'''~~

===N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)===

~~==Overview==~~

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The ~~structure of~~ the ~~functional N-terminal domain from~~ the ~~extracellular region of the cell surface receptor sialoadhesin has been determined in complex with the oligosaccharide 3' sialyllactose~~. ~~This provides structural information for the siglec family of proteins~~. ~~The structure conforms to the V-set immunoglobulin-like fold but contains several distinctive features~~, ~~including an intra-beta sheet disulphide and a splitting of~~ the ~~standard beta strand G into two shorter strands~~. ~~These novel features appear important in adapting the V~~-~~set fold for sialic acid~~-mediated recognition. Analysis of the complex with 3'sialyllactose highlights three residues, conserved throughout the siglec family, as key features of the sialic acid-binding template. The complex is representative of the functional recognition interaction with carbohydrate and as such provides detailed information for a heterotypic cell adhesion interaction.

The line below this paragraph, {{ABSTRACT_PUBMED_9660955}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9660955 is the PubMed ID number.

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==About this Structure==

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[[Category: Carbohydrate binding]]

[[Category: Immunoglobulin superfamily]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:12:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:11:08 2008''

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-[[Image:1qfp.gif|left|200px]]
+{{Seed}}
+[[Image:1qfp.png|left|200px]]
 <!--
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 {{STRUCTURE_1qfp|  PDB=1qfp  |  SCENE=  }}
-'''N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)'''
+===N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE)===
-==Overview==
+<!--
-The structure of the functional N-terminal domain from the extracellular region of the cell surface receptor sialoadhesin has been determined in complex with the oligosaccharide 3' sialyllactose. This provides structural information for the siglec family of proteins. The structure conforms to the V-set immunoglobulin-like fold but contains several distinctive features, including an intra-beta sheet disulphide and a splitting of the standard beta strand G into two shorter strands. These novel features appear important in adapting the V-set fold for sialic acid-mediated recognition. Analysis of the complex with 3'sialyllactose highlights three residues, conserved throughout the siglec family, as key features of the sialic acid-binding template. The complex is representative of the functional recognition interaction with carbohydrate and as such provides detailed information for a heterotypic cell adhesion interaction.
+The line below this paragraph, {{ABSTRACT_PUBMED_9660955}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9660955 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9660955}}
 ==About this Structure==
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 [[Category: Carbohydrate binding]]
 [[Category: Immunoglobulin superfamily]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:12:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:11:08 2008''