2h0p: Difference between revisions

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[[Image:2h0p.~~gif~~|left|200px]]

[[Image:2h0p.png|left|200px]]

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~~'''~~NMR Structure of the Dengue-4 virus Envelope Protein Domain III~~'''~~

===NMR Structure of the Dengue-4 virus Envelope Protein Domain III===

~~==Overview==~~

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The ~~disease dengue (DEN) is caused by four serologically related viruses termed DEN1~~, ~~DEN2~~, ~~DEN3 and DEN4. The structure of~~ the ~~ectodomain of~~ the ~~envelope protein has been determined previously for DEN2 and DEN3 viruses~~. ~~Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3~~), the ~~receptor~~-~~binding domain, of the envelope protein of DEN4 virus, human strain 703~~-4. The structure shows that the nine amino acid changes in ED3 that separate the sylvatic and human DEN4 strains are surface exposed. Important structural differences between DEN4-rED3 and ED3 domains of DEN2, DEN3 and other flaviviruses are discussed.

The line below this paragraph, {{ABSTRACT_PUBMED_17395234}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17395234 is the PubMed ID number.

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==About this Structure==

2H0P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0P OCA].

2H0P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0P OCA].

==Reference==

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[[Category: Beta sandwich]]

[[Category: Ig-fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:43:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:17:17 2008''

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-[[Image:2h0p.gif|left|200px]]
+{{Seed}}
+[[Image:2h0p.png|left|200px]]
 <!--
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 {{STRUCTURE_2h0p|  PDB=2h0p  |  SCENE=  }}
-'''NMR Structure of the Dengue-4 virus Envelope Protein Domain III'''
+===NMR Structure of the Dengue-4 virus Envelope Protein Domain III===
-==Overview==
+<!--
-The disease dengue (DEN) is caused by four serologically related viruses termed DEN1, DEN2, DEN3 and DEN4. The structure of the ectodomain of the envelope protein has been determined previously for DEN2 and DEN3 viruses. Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4. The structure shows that the nine amino acid changes in ED3 that separate the sylvatic and human DEN4 strains are surface exposed. Important structural differences between DEN4-rED3 and ED3 domains of DEN2, DEN3 and other flaviviruses are discussed.
+The line below this paragraph, {{ABSTRACT_PUBMED_17395234}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17395234 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17395234}}
 ==About this Structure==
-H0P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0P OCA].
+H0P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_4 Dengue virus 4]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0P OCA].
 ==Reference==
@@ Line 30: / Line 34: @@
 [[Category: Beta sandwich]]
 [[Category: Ig-fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:43:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:17:17 2008''