2cdx: Difference between revisions

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[[Image:2cdx.jpg|left|200px]]
{{Seed}}
[[Image:2cdx.png|left|200px]]


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{{STRUCTURE_2cdx|  PDB=2cdx  |  SCENE=  }}  
{{STRUCTURE_2cdx|  PDB=2cdx  |  SCENE=  }}  


'''STRUCTURE OF COBRA CARDIOTOXIN CTXI AS DERIVED FROM NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DISTANCE GEOMETRY CALCULATIONS'''
===STRUCTURE OF COBRA CARDIOTOXIN CTXI AS DERIVED FROM NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DISTANCE GEOMETRY CALCULATIONS===




==Overview==
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The structure of cardiotoxin CTX I from Naja naja atra has been investigated by NMR spectroscopy. Sequence specific resonance assignments have been obtained for all backbone protons as well as for most side-chain protons. Distance geometry calculations were carried out using a metric matrix DG program. A total of 715 NOE constraints, 27 phi angle constraints and a list of the hydrogen bond donors were used for the metric matrix DG calculations and refinement. The average pairwise r.m.s.d. of the resulting structures was 1.01 A for the backbone heavy atoms, and 1.69 A for all heavy atoms. The protein is rich in beta structure and consists of a large triple-stranded, antiparallel beta sheet as well as a short double-stranded, antiparallel beta sheet. Non-regular hydrogen bonding is found between side-chains of the carboxy-terminal end and the rest of the core region. The structure is discussed in terms of evolutionary aspects as well as recent investigations about the biological function and active site.
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{{ABSTRACT_PUBMED_8046750}}


==About this Structure==
==About this Structure==
2CDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDX OCA].  
2CDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CDX OCA].  


==Reference==
==Reference==
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[[Category: Mierke, D F.]]
[[Category: Mierke, D F.]]
[[Category: Cardiotoxin]]
[[Category: Cardiotoxin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 21:54:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:20:58 2008''

Revision as of 13:21, 28 July 2008

File:2cdx.png

Template:STRUCTURE 2cdx

STRUCTURE OF COBRA CARDIOTOXIN CTXI AS DERIVED FROM NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND DISTANCE GEOMETRY CALCULATIONS

Template:ABSTRACT PUBMED 8046750

About this Structure

2CDX is a Single protein structure of sequence from Naja atra. Full experimental information is available from OCA.

Reference

Structure of cobra cardiotoxin CTX I as derived from nuclear magnetic resonance spectroscopy and distance geometry calculations., Jahnke W, Mierke DF, Beress L, Kessler H, J Mol Biol. 1994 Jul 29;240(5):445-58. PMID:8046750

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