1pmd: Difference between revisions

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[[Image:1pmd.gif|left|200px]]
{{Seed}}
[[Image:1pmd.png|left|200px]]


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{{STRUCTURE_1pmd|  PDB=1pmd  |  SCENE=  }}  
{{STRUCTURE_1pmd|  PDB=1pmd  |  SCENE=  }}  


'''PENICILLIN-BINDING PROTEIN 2X (PBP-2X)'''
===PENICILLIN-BINDING PROTEIN 2X (PBP-2X)===




==Overview==
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All beta-lactam antibiotics exert their biological effects by interacting with a unique class of proteins, the penicillin-binding proteins (PBPs). These membrane proteins are involved in the biosynthesis of the murein or peptidoglycan, a mesh-like structure which completely surrounds the bacterial cell. Sequence similarities indicate that one domain of these proteins belongs to a large family of beta-lactam-recognizing proteins, which includes the active-site serine beta-lactamases. We here report the first three-dimensional crystal structure of a high molecular weight penicillin-binding protein, PBP2x of Streptococcus pneumoniae, at 3.5 A resolution. The molecule has three domains, the central domain being a transpeptidase, which is a suitable target for antibiotic development.
The line below this paragraph, {{ABSTRACT_PUBMED_8605631}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8605631 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8605631}}


==About this Structure==
==About this Structure==
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[[Category: Resistance]]
[[Category: Resistance]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:14:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:26:52 2008''

Revision as of 13:26, 28 July 2008

File:1pmd.png

Template:STRUCTURE 1pmd

PENICILLIN-BINDING PROTEIN 2X (PBP-2X)

Template:ABSTRACT PUBMED 8605631

About this Structure

1PMD is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

X-ray structure of Streptococcus pneumoniae PBP2x, a primary penicillin target enzyme., Pares S, Mouz N, Petillot Y, Hakenbeck R, Dideberg O, Nat Struct Biol. 1996 Mar;3(3):284-9. PMID:8605631

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