1uzi: Difference between revisions

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~~'''~~C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM~~'''~~

===C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM===

~~==Overview==~~

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~~C3 exoenzyme from Clostridium botulinum (C3bot1) ADP-ribosylates and thereby inactivates Rho A~~, ~~B and C GTPases in mammalian cells. The structure of a tetragonal crystal form has been determined by molecular replacement and refined~~ to 1.~~89 A resolution~~. It is ~~very similar to~~ the ~~apo structures determined previously from two different monoclinic crystal forms~~. ~~An objective reassessment of available apo and nucleotide~~-~~bound C3bot1 structures indicates that, contrary to a previous report, the protein possesses a rigid core formed largely of beta~~-strands and that the general flexure that accompanies NAD binding is concentrated in two peripheral lobes. Tetragonal crystals disintegrate in the presence of NAD, most likely because of disruption of essential crystal contacts.

The line below this paragraph, {{ABSTRACT_PUBMED_15272191}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15272191 is the PubMed ID number.

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==About this Structure==

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[[Category: C3]]

[[Category: Transferase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 11~~:54:21 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:33:09 2008''

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-[[Image:1uzi.jpg|left|200px]]
+{{Seed}}
+[[Image:1uzi.png|left|200px]]
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 {{STRUCTURE_1uzi|  PDB=1uzi  |  SCENE=  }}
-'''C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM'''
+===C3 EXOENZYME FROM CLOSTRIDIUM BOTULINUM, TETRAGONAL FORM===
-==Overview==
+<!--
-C3 exoenzyme from Clostridium botulinum (C3bot1) ADP-ribosylates and thereby inactivates Rho A, B and C GTPases in mammalian cells. The structure of a tetragonal crystal form has been determined by molecular replacement and refined to 1.89 A resolution. It is very similar to the apo structures determined previously from two different monoclinic crystal forms. An objective reassessment of available apo and nucleotide-bound C3bot1 structures indicates that, contrary to a previous report, the protein possesses a rigid core formed largely of beta-strands and that the general flexure that accompanies NAD binding is concentrated in two peripheral lobes. Tetragonal crystals disintegrate in the presence of NAD, most likely because of disruption of essential crystal contacts.
+The line below this paragraph, {{ABSTRACT_PUBMED_15272191}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15272191 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15272191}}
 ==About this Structure==
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 [[Category: C3]]
 [[Category: Transferase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 11:54:21 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:33:09 2008''