2adb: Difference between revisions

Line 1:

[[Image:2adb.~~gif~~|left|200px]]

[[Image:2adb.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA~~'''~~

===Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA===

~~==Overview==~~

<!--

The ~~polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism~~, ~~including~~ the ~~repression of alternative exons. We have determined~~ the ~~solution structures of the four RNA binding domains~~ (~~RBDs) of PTB, each bound to a CUCUCU oligonucleotide~~. ~~Each RBD binds RNA with a different binding specificity~~. ~~RBD3 and RBD4 interact~~, ~~resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within~~ the ~~same RNA~~. ~~This leads to structural models for how PTB functions as an alternative~~-~~splicing repressor.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16179478}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16179478 is the PubMed ID number.

-->

==About this Structure==

2ADB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].

2ADB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].

==Reference==

Line 35:

Line 39:

[[Category: Rbd]]

[[Category: Rrm]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 18~~:54:11 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:37:59 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2adb.gif|left|200px]]
+{{Seed}}
+[[Image:2adb.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2adb|  PDB=2adb  |  SCENE=  }}
-'''Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA'''
+===Solution structure of Polypyrimidine Tract Binding protein RBD2 complexed with CUCUCU RNA===
-==Overview==
+<!--
-The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA binding protein involved in multiple aspects of messenger RNA metabolism, including the repression of alternative exons. We have determined the solution structures of the four RNA binding domains (RBDs) of PTB, each bound to a CUCUCU oligonucleotide. Each RBD binds RNA with a different binding specificity. RBD3 and RBD4 interact, resulting in an antiparallel orientation of their bound RNAs. Thus, PTB will induce RNA looping when bound to two separated pyrimidine tracts within the same RNA. This leads to structural models for how PTB functions as an alternative-splicing repressor.
+The line below this paragraph, {{ABSTRACT_PUBMED_16179478}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16179478 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16179478}}
 ==About this Structure==
-ADB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].
+ADB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ADB OCA].
 ==Reference==
@@ Line 35: / Line 39: @@
 [[Category: Rbd]]
 [[Category: Rrm]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 18:54:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:37:59 2008''