1svq: Difference between revisions

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[[Image:1svq.gif|left|200px]]
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[[Image:1svq.png|left|200px]]


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{{STRUCTURE_1svq|  PDB=1svq  |  SCENE=  }}  
{{STRUCTURE_1svq|  PDB=1svq  |  SCENE=  }}  


'''STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION'''
===STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION===




==Overview==
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The three-dimensional structure of domain 2 of severin in aqueous solution was determined by nuclear magnetic resonance spectroscopy. Severin is a Ca(2+)-activated actin-binding protein that servers F-actin, nucleates actin assembly, and caps the fast-growing ends of actin filaments. The 114-residue domain consists of a central five-stranded beta-sheet, sandwiched between a parallel four-turn alpha-helix and, on the other face, a roughly perpendicular two-turn alpha-helix. There are two distinct binding sites for Ca2+ located near the N and C termini of the long helix. Conserved residues of the gelsolin-severin family contribute to the apolar core of domain 2 of severin, so that the overall fold of the protein is similar to those of segment 1 of gelsolin and profilins. Together with biochemical experiments, this structure helps to explain how severin interacts with actin.
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{{ABSTRACT_PUBMED_7897658}}


==About this Structure==
==About this Structure==
1SVQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVQ OCA].  
1SVQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SVQ OCA].  


==Reference==
==Reference==
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[[Category: Schnuchel, A.]]
[[Category: Schnuchel, A.]]
[[Category: Actin-binding]]
[[Category: Actin-binding]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:11:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:42:38 2008''

Revision as of 13:42, 28 July 2008

File:1svq.png

Template:STRUCTURE 1svq

STRUCTURE OF SEVERIN DOMAIN 2 IN SOLUTION

Template:ABSTRACT PUBMED 7897658

About this Structure

1SVQ is a Single protein structure of sequence from Dictyostelium discoideum. Full experimental information is available from OCA.

Reference

Structure of severin domain 2 in solution., Schnuchel A, Wiltscheck R, Eichinger L, Schleicher M, Holak TA, J Mol Biol. 1995 Mar 17;247(1):21-7. PMID:7897658

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