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| {{STRUCTURE_2oyp| PDB=2oyp | SCENE= }} | | {{STRUCTURE_2oyp| PDB=2oyp | SCENE= }} |
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| '''T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface'''
| | ===T Cell Immunoglobulin Mucin-3 Crystal Structure Revealed a Galectin-9-independent Binding Surface=== |
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| ==Overview==
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| The T cell immunoglobulin mucin (Tim) family of receptors regulates effector CD4(+) T cell functions and is implicated in autoimmune and allergic diseases. Tim-3 induces immunological tolerance, and engagement of the Tim-3 immunoglobulin variable (IgV) domain by galectin-9 is important for appropriate termination of T helper 1-immune responses. The 2 A crystal structure of the Tim-3 IgV domain demonstrated that four cysteines, which are invariant within the Tim family, form two noncanonical disulfide bonds, resulting in a surface not present in other immunoglobulin superfamily members. Biochemical and biophysical studies demonstrated that this unique structural feature mediates a previously unidentified galectin-9-independent binding process and suggested that this structural feature is conserved within the entire Tim family. The current work provided a graphic example of the relationship between sequence, structure, and function and suggested that the interplay between multiple Tim-3-binding activities contributes to the regulated assembly of signaling complexes required for effective Th1-mediated immunity. | | The line below this paragraph, {{ABSTRACT_PUBMED_17363302}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 17363302 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_17363302}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: T-cell immunoglobulin mucin]] | | [[Category: T-cell immunoglobulin mucin]] |
| [[Category: Tim-3]] | | [[Category: Tim-3]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 11:56:40 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:54:11 2008'' |
