2com: Difference between revisions

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[[Image:2com.gif|left|200px]]
{{Seed}}
[[Image:2com.png|left|200px]]


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{{STRUCTURE_2com|  PDB=2com  |  SCENE=  }}  
{{STRUCTURE_2com|  PDB=2com  |  SCENE=  }}  


'''The solution structure of the SWIRM domain of human LSD1'''
===The solution structure of the SWIRM domain of human LSD1===




==Overview==
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SWIRM is an evolutionarily conserved domain involved in several chromatin-modifying complexes. Recently, the LSD1 protein, which bears a SWIRM domain, was found to be a demethylase for Lys4-methylated histone H3. Here, we report a solution structure of the SWIRM domain of human LSD1. It forms a compact fold composed of 6 alpha helices, in which a 20 amino acid long helix (alpha4) is surrounded by 5 other short helices. The SWIRM domain structure could be divided into the N-terminal part (alpha1-alpha3) and the C-terminal part (alpha4-alpha6), which are connected to each other by a salt bridge. While the N-terminal part forms a SWIRM-specific structure, the C-terminal part adopts a helix-turn-helix (HTH)-related fold. We discuss a model in which the SWIRM domain acts as an anchor site for a histone tail.
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{{ABSTRACT_PUBMED_16531230}}


==About this Structure==
==About this Structure==
2COM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COM OCA].  
2COM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2COM OCA].  


==Reference==
==Reference==
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[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Swirm domain]]
[[Category: Swirm domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 22:40:38 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:01:55 2008''
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