2j68: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:2j68.jpg|left|200px]]
{{Seed}}
[[Image:2j68.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2j68|  PDB=2j68  |  SCENE=  }}  
{{STRUCTURE_2j68|  PDB=2j68  |  SCENE=  }}  


'''BACTERIAL DYNAMIN-LIKE PROTEIN BDLP, GDP BOUND'''
===BACTERIAL DYNAMIN-LIKE PROTEIN BDLP, GDP BOUND===




==Overview==
<!--  
Dynamins form a superfamily of large mechano-chemical GTPases that includes the classical dynamins and dynamin-like proteins (DLPs). They are found throughout the Eukarya, functioning in core cellular processes such as endocytosis and organelle division. Many bacteria are predicted by sequence to possess large GTPases with the same multidomain architecture that is found in DLPs. Mechanistic dissection of dynamin family members has been impeded by a lack of high-resolution structural data currently restricted to the GTPase and pleckstrin homology domains, and the dynamin-related human guanylate-binding protein. Here we present the crystal structure of a cyanobacterial DLP in both nucleotide-free and GDP-associated conformation. The bacterial DLP shows dynamin-like qualities, such as helical self-assembly and tubulation of a lipid bilayer. In vivo, it localizes to the membrane in a manner reminiscent of FZL, a chloroplast-specific dynamin-related protein with which it shares sequence similarity. Our results provide structural and mechanistic insight that may be relevant across the dynamin superfamily. Concurrently, we show compelling similarity between a cyanobacterial and chloroplast DLP that, given the endosymbiotic ancestry of chloroplasts, questions the evolutionary origins of dynamins.
The line below this paragraph, {{ABSTRACT_PUBMED_17122778}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17122778 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17122778}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Gtpase]]
[[Category: Gtpase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 08:24:04 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:22:51 2008''

Revision as of 14:22, 28 July 2008

File:2j68.png

Template:STRUCTURE 2j68

BACTERIAL DYNAMIN-LIKE PROTEIN BDLP, GDP BOUND

Template:ABSTRACT PUBMED 17122778

About this Structure

2J68 is a Single protein structure of sequence from Nostoc punctiforme. Full crystallographic information is available from OCA.

Reference

A bacterial dynamin-like protein., Low HH, Lowe J, Nature. 2006 Dec 7;444(7120):766-9. Epub 2006 Nov 22. PMID:17122778

Page seeded by OCA on Mon Jul 28 17:22:51 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2j68&oldid=709014"