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| {{STRUCTURE_2frg| PDB=2frg | SCENE= }} | | {{STRUCTURE_2frg| PDB=2frg | SCENE= }} |
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| '''Structure of the immunoglobulin-like domain of human TLT-1'''
| | ===Structure of the immunoglobulin-like domain of human TLT-1=== |
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| ==Overview==
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| Triggering receptor expressed on myeloid cells like transcript-1 (TLT-1) is an abundant platelet-specific, type I transmembrane receptor. The extracellular fragment of TLT-1 consists of a single, immunoglobulin-like domain connected to the platelet cell membrane by a linker region called the stalk. Here we present evidence that a soluble fragment of the TLT-1 extracellular domain is found in serum of humans and mice and that an isoform of similar mass is released from platelets following activation with thrombin. We also report the crystal structure of the immunoglobulin domain of TLT-1 determined at the resolution of 1.19 A. The structure of TLT-1 is similar to other immunoglobulin-like variable domains, particularly those of triggering receptor expressed on myeloid cells-1 (TREM-1), the natural killer cell-activating receptor NKp44, and the polymeric immunoglobulin receptor. Particularly interesting is a 17-amino acid segment of TLT-1, homologous to a fragment of murine TREM-1, which, in turn, showed activity in blocking the TREM-1-mediated inflammatory responses in mice. Structural similarity to TREM-1 and polymeric immunoglobulin receptor, and evidence for a naturally occurring soluble fragment of the TLT-1 extracellular domain, suggest that this immunoglobulin-like domain autonomously plays an as yet unidentified, functional role.
| | The line below this paragraph, {{ABSTRACT_PUBMED_16505478}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16505478 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16505478}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Trem-like]] | | [[Category: Trem-like]] |
| [[Category: Triggering receptor]] | | [[Category: Triggering receptor]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 04:13:45 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:26:29 2008'' |
