1odg: Difference between revisions

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[[Image:1odg.~~gif~~|left|200px]]

[[Image:1odg.png|left|200px]]

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~~'''~~VERY-SHORT-PATCH DNA REPAIR ENDONUCLEASE BOUND TO ITS REACTION PRODUCT SITE~~'''~~

===VERY-SHORT-PATCH DNA REPAIR ENDONUCLEASE BOUND TO ITS REACTION PRODUCT SITE===

~~==Overview==~~

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~~Very~~-~~short~~-~~patch repair (Vsr) enzymes occur in a variety of bacteria~~, ~~where they initiate nucleotide excision repair of G:T mismatches arising by deamination of 5-methyl-cytosines in specific regulatory sequences. We have now determined~~ the ~~structure of the archetypal dcm-Vsr endonuclease from Escherichia coli bound~~ to the ~~cleaved authentic hemi-deaminated~~/~~hemi-methylated dcm sequence 5'-C-OH-3' 5'-p-T-p-A-p-G-p-G-3'~~/~~3'-G-p-G-p-T-p(Me5~~)C-p-C formed by self-assembly of a 12mer oligonucleotide into a continuous nicked DNA superhelix. The structure reveals the presence of a Hoogsteen base pair within the deaminated recognition sequence and the substantial distortions of the DNA that accompany Vsr binding to product sites.

The line below this paragraph, {{ABSTRACT_PUBMED_12626704}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12626704 is the PubMed ID number.

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==About this Structure==

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[[Category: Very short patch repair]]

[[Category: Zinc]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 03~~:42:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:40:14 2008''

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-[[Image:1odg.gif|left|200px]]
+{{Seed}}
+[[Image:1odg.png|left|200px]]
 <!--
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 {{STRUCTURE_1odg|  PDB=1odg  |  SCENE=  }}
-'''VERY-SHORT-PATCH DNA REPAIR ENDONUCLEASE BOUND TO ITS REACTION PRODUCT SITE'''
+===VERY-SHORT-PATCH DNA REPAIR ENDONUCLEASE BOUND TO ITS REACTION PRODUCT SITE===
-==Overview==
+<!--
-Very-short-patch repair (Vsr) enzymes occur in a variety of bacteria, where they initiate nucleotide excision repair of G:T mismatches arising by deamination of 5-methyl-cytosines in specific regulatory sequences. We have now determined the structure of the archetypal dcm-Vsr endonuclease from Escherichia coli bound to the cleaved authentic hemi-deaminated/hemi-methylated dcm sequence 5'-C-OH-3' 5'-p-T-p-A-p-G-p-G-3'/3'-G-p-G-p-T-p(Me5)C-p-C formed by self-assembly of a 12mer oligonucleotide into a continuous nicked DNA superhelix. The structure reveals the presence of a Hoogsteen base pair within the deaminated recognition sequence and the substantial distortions of the DNA that accompany Vsr binding to product sites.
+The line below this paragraph, {{ABSTRACT_PUBMED_12626704}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12626704 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12626704}}
 ==About this Structure==
@@ Line 35: / Line 39: @@
 [[Category: Very short patch repair]]
 [[Category: Zinc]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:42:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:40:14 2008''