1ocm: Difference between revisions

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[[Image:1ocm.gif|left|200px]]
{{Seed}}
[[Image:1ocm.png|left|200px]]


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{{STRUCTURE_1ocm|  PDB=1ocm  |  SCENE=  }}  
{{STRUCTURE_1ocm|  PDB=1ocm  |  SCENE=  }}  


'''THE CRYSTAL STRUCTURE OF MALONAMIDASE E2 COVALENTLY COMPLEXED WITH PYROPHOSPHATE FROM BRADYRHIZOBIUM JAPONICUM'''
===THE CRYSTAL STRUCTURE OF MALONAMIDASE E2 COVALENTLY COMPLEXED WITH PYROPHOSPHATE FROM BRADYRHIZOBIUM JAPONICUM===




==Overview==
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A large group of hydrolytic enzymes, which contain a conserved stretch of approximately 130 amino acids designated the amidase signature (AS) sequence, constitutes a super family that is distinct from any other known hydrolase family. AS family enzymes are widespread in nature, ranging from bacteria to humans, and exhibit a variety of biological functions. Here we report the first structure of an AS family enzyme provided by the crystal structure of malonamidase E2 from Bradyrhizobium japonicum. The structure, representing a new protein fold, reveals a previously unidentified Ser-cisSer-Lys catalytic machinery that is absolutely conserved throughout the family. This family of enzymes appears to be evolutionarily distinct but has diverged to acquire a wide spectrum of individual substrate specificities, while maintaining a core structure that supports the catalytic function of the unique triad. Based of the structures of the enzyme in two different inhibited states, an unusual action mechanism of the triad is proposed that accounts for the role of the cis conformation in the triad.
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{{ABSTRACT_PUBMED_12032064}}


==About this Structure==
==About this Structure==
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[[Category: Amidase]]
[[Category: Amidase]]
[[Category: Malonamidase]]
[[Category: Malonamidase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:40:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:45:58 2008''

Revision as of 14:46, 28 July 2008

File:1ocm.png

Template:STRUCTURE 1ocm

THE CRYSTAL STRUCTURE OF MALONAMIDASE E2 COVALENTLY COMPLEXED WITH PYROPHOSPHATE FROM BRADYRHIZOBIUM JAPONICUM

Template:ABSTRACT PUBMED 12032064

About this Structure

1OCM is a Single protein structure of sequence from Bradyrhizobium japonicum. This structure supersedes the now removed PDB entry 1grk. Full crystallographic information is available from OCA.

Reference

Structure of malonamidase E2 reveals a novel Ser-cisSer-Lys catalytic triad in a new serine hydrolase fold that is prevalent in nature., Shin S, Lee TH, Ha NC, Koo HM, Kim SY, Lee HS, Kim YS, Oh BH, EMBO J. 2002 Jun 3;21(11):2509-16. PMID:12032064

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