1mzc: Difference between revisions

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[[Image:1mzc.~~jpg~~|left|200px]]

[[Image:1mzc.png|left|200px]]

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~~'''~~Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a~~'''~~

===Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a===

~~==Overview==~~

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~~A series of novel diaryl ether lactams have been identified~~ as ~~very potent dual inhibitors of protein farnesyltransferase (FTase) and protein geranylgeranyltransferase I (GGTase-I~~), ~~enzymes involved in~~ the ~~prenylation of Ras~~. ~~The structure of the complex formed between one of these compounds and FTase has been determined by X~~-~~ray crystallography. These compounds are the first reported to inhibit the prenylation of the important oncogene Ki~~-~~Ras4B in vivo. Unfortunately, doses sufficient to achieve this endpoint were rapidly lethal.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12825937}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12825937 is the PubMed ID number.

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==About this Structure==

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[[Category: Pftase]]

[[Category: Ra]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 01~~:53:39 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:47:08 2008''

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-[[Image:1mzc.jpg|left|200px]]
+{{Seed}}
+[[Image:1mzc.png|left|200px]]
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 {{STRUCTURE_1mzc|  PDB=1mzc  |  SCENE=  }}
-'''Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a'''
+===Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a===
-==Overview==
+<!--
-A series of novel diaryl ether lactams have been identified as very potent dual inhibitors of protein farnesyltransferase (FTase) and protein geranylgeranyltransferase I (GGTase-I), enzymes involved in the prenylation of Ras. The structure of the complex formed between one of these compounds and FTase has been determined by X-ray crystallography. These compounds are the first reported to inhibit the prenylation of the important oncogene Ki-Ras4B in vivo. Unfortunately, doses sufficient to achieve this endpoint were rapidly lethal.
+The line below this paragraph, {{ABSTRACT_PUBMED_12825937}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12825937 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12825937}}
 ==About this Structure==
@@ Line 46: / Line 50: @@
 [[Category: Pftase]]
 [[Category: Ra]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 01:53:39 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:47:08 2008''