1pe3: Difference between revisions

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[[Image:1pe3.gif|left|200px]]
{{Seed}}
[[Image:1pe3.png|left|200px]]


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{{STRUCTURE_1pe3|  PDB=1pe3  |  SCENE=  }}  
{{STRUCTURE_1pe3|  PDB=1pe3  |  SCENE=  }}  


'''Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)'''
===Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)===




==Overview==
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The trefoil protein TFF3 forms a homodimer (via a disulfide linkage) that is thought to have increased biological activity over the monomer. The solution structure of the TFF3 dimer has been determined by NMR and compared with the structure of the TFF3 monomer and with other trefoil dimer structures (TFF1 and TFF2). The most significant structural differences between the trefoil domain in the monomer and dimer TFF3 are in the orientations of the N-terminal 3(10)-helix (residues 10-12) and in the presence in the dimer of an additional 3(10)-helix (residues 53-55) outside of the core region. The TFF3 dimer forms a more compact structure as compared with the TFF1 dimer where the two trefoil domains are connected by a flexible region with the monomer units being at variable distances from each other and in many different orientations. Although TFF2 is also a compact structure, the dispositions of its monomer units are very different from those of TFF3. The structural differences between the dimers result in the two putative receptor/ligand binding sites that remain solvent exposed in the dimeric structures having very different dispositions in the different dimers. Such differences have significant implications for the mechanism of action and functional specificity for the TFF class of proteins.
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{{ABSTRACT_PUBMED_14690424}}


==About this Structure==
==About this Structure==
1PE3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE3 OCA].  
1PE3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PE3 OCA].  


==Reference==
==Reference==
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[[Category: Trefoil factor family]]
[[Category: Trefoil factor family]]
[[Category: Trefoil motif]]
[[Category: Trefoil motif]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:58:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:47:40 2008''

Revision as of 14:47, 28 July 2008

File:1pe3.png

Template:STRUCTURE 1pe3

Solution structure of the disulphide-linked dimer of human intestinal trefoil factor (TFF3)

Template:ABSTRACT PUBMED 14690424

About this Structure

1PE3 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins., Muskett FW, May FE, Westley BR, Feeney J, Biochemistry. 2003 Dec 30;42(51):15139-47. PMID:14690424

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