2zaz: Difference between revisions

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[[Image:2zaz.jpg|left|200px]]
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[[Image:2zaz.png|left|200px]]


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{{STRUCTURE_2zaz|  PDB=2zaz  |  SCENE=  }}  
{{STRUCTURE_2zaz|  PDB=2zaz  |  SCENE=  }}  


'''Crystal structure of P38 in complex with 4-anilino quinoline inhibitor'''
===Crystal structure of P38 in complex with 4-anilino quinoline inhibitor===




==Overview==
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The biphenyl amides (BPAs) are a novel series of p38 MAP kinase inhibitors. The discovery of the series through structure-based focused screening is described, and the binding mode of the compounds is explained with reference to X-ray crystal structures.
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{{ABSTRACT_PUBMED_18006306}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine protein kinase]]
[[Category: Serine/threonine protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 20:06:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:46:26 2008''

Revision as of 15:46, 28 July 2008

File:2zaz.png

Template:STRUCTURE 2zaz

Crystal structure of P38 in complex with 4-anilino quinoline inhibitor

Template:ABSTRACT PUBMED 18006306

About this Structure

2ZAZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode., Angell RM, Bamborough P, Cleasby A, Cockerill SG, Jones KL, Mooney CJ, Somers DO, Walker AL, Bioorg Med Chem Lett. 2008 Jan 1;18(1):318-23. Epub 2007 Nov 19. PMID:18006306

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