2bi6: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:2bi6.jpg|left|200px]]
{{Seed}}
[[Image:2bi6.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2bi6|  PDB=2bi6  |  SCENE=  }}  
{{STRUCTURE_2bi6|  PDB=2bi6  |  SCENE=  }}  


'''NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM'''
===NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM===




==Overview==
<!--  
Bromelain inhibitor VI from pineapple stem (BI-VI) is a unique double-chain inhibitor with an 11-residue light chain and a 41-residue heavy chain by disulfide bonds and inhibits the cysteine proteinase bromelain competitively. The structure of BI-VI in aqueous solution was determined using nuclear magnetic resonance spectroscopy and simulated annealing-based calculations. Its three-dimensional structure was shown to be composed of two distinct domains, each of which is formed by a three-stranded antiparallel beta-sheet. Unexpectedly, BI-VI was found to share a similar folding and disulfide bond connectivities not with cystatin superfamily inhibitors which inhibit the same cysteine proteinases but with the Bowman-Birk trypsin/chymotrypsin inhibitor from soybean (BBI-I). BBI-I is a 71-residue inhibitor which has two independent inhibitory sites toward the serine proteinases trypsin and chymotrypsin. These structural similarities with BBI-I suggest that they have evolved from a common ancestor and differentiated in function during a course of molecular evolution.
The line below this paragraph, {{ABSTRACT_PUBMED_8611527}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8611527 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8611527}}


==About this Structure==
==About this Structure==
2BI6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI6 OCA].  
2BI6 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Ananas_comosus Ananas comosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BI6 OCA].  


==Reference==
==Reference==
Line 24: Line 28:
[[Category: Hatano, K I.]]
[[Category: Hatano, K I.]]
[[Category: Cysteine protease inhibitor]]
[[Category: Cysteine protease inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 20:19:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:55:46 2008''

Revision as of 15:55, 28 July 2008

File:2bi6.png

Template:STRUCTURE 2bi6

NMR STUDY OF BROMELAIN INHIBITOR VI FROM PINEAPPLE STEM

Template:ABSTRACT PUBMED 8611527

About this Structure

2BI6 is a Protein complex structure of sequences from Ananas comosus. Full experimental information is available from OCA.

Reference

Solution structure of bromelain inhibitor IV from pineapple stem: structural similarity with Bowman-Birk trypsin/chymotrypsin inhibitor from soybean., Hatano K, Kojima M, Tanokura M, Takahashi K, Biochemistry. 1996 Apr 30;35(17):5379-84. PMID:8611527

Page seeded by OCA on Mon Jul 28 18:55:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2bi6&oldid=711006"