2fd4: Difference between revisions

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[[Image:2fd4.gif|left|200px]]
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[[Image:2fd4.png|left|200px]]


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{{STRUCTURE_2fd4|  PDB=2fd4  |  SCENE=  }}  
{{STRUCTURE_2fd4|  PDB=2fd4  |  SCENE=  }}  


'''Crystal Structure of AvrPtoB (436-553)'''
===Crystal Structure of AvrPtoB (436-553)===




==Overview==
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The Pseudomonas syringae protein AvrPtoB is translocated into plant cells, where it inhibits immunity-associated programmed cell death (PCD). The structure of a C-terminal domain of AvrPtoB that is essential for anti-PCD activity reveals an unexpected homology to the U-box and RING-finger components of eukaryotic E3 ubiquitin ligases, and we show that AvrPtoB has ubiquitin ligase activity. Mutation of conserved residues involved in the binding of E2 ubiquitin-conjugating enzymes abolishes this activity in vitro, as well as anti-PCD activity in tomato leaves, which dramatically decreases virulence. These results show that Pseudomonas syringae uses a mimic of host E3 ubiquitin ligases to inactivate plant defenses.
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{{ABSTRACT_PUBMED_16373536}}


==About this Structure==
==About this Structure==
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[[Category: U-box]]
[[Category: U-box]]
[[Category: Ubiquitin ligase]]
[[Category: Ubiquitin ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:02:56 2008''

Revision as of 16:03, 28 July 2008

File:2fd4.png

Template:STRUCTURE 2fd4

Crystal Structure of AvrPtoB (436-553)

Template:ABSTRACT PUBMED 16373536

About this Structure

2FD4 is a Single protein structure of sequence from Pseudomonas syringae. Full crystallographic information is available from OCA.

Reference

A bacterial inhibitor of host programmed cell death defenses is an E3 ubiquitin ligase., Janjusevic R, Abramovitch RB, Martin GB, Stebbins CE, Science. 2006 Jan 13;311(5758):222-6. Epub 2005 Dec 22. PMID:16373536

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