1xzz: Difference between revisions

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[[Image:1xzz.gif|left|200px]]
{{Seed}}
[[Image:1xzz.png|left|200px]]


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{{STRUCTURE_1xzz|  PDB=1xzz  |  SCENE=  }}  
{{STRUCTURE_1xzz|  PDB=1xzz  |  SCENE=  }}  


'''Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor'''
===Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor===




==Overview==
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Binding of inositol 1,4,5-trisphosphate (IP(3)) to the amino-terminal region of IP(3) receptor promotes Ca(2+) release from the endoplasmic reticulum. Within the amino terminus, the first 220 residues directly preceding the IP(3) binding core domain play a key role in IP(3) binding suppression and regulatory protein interaction. Here we present a crystal structure of the suppressor domain of the mouse type 1 IP(3) receptor at 1.8 A. Displaying a shape akin to a hammer, the suppressor region contains a Head subdomain forming the beta-trefoil fold and an Arm subdomain possessing a helix-turn-helix structure. The conserved region on the Head subdomain appeared to interact with the IP(3) binding core domain and is in close proximity to the previously proposed binding sites of Homer, RACK1, calmodulin, and CaBP1. The present study sheds light onto the mechanism underlying the receptor's sensitivity to the ligand and its communication with cellular signaling proteins.
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{{ABSTRACT_PUBMED_15664189}}


==About this Structure==
==About this Structure==
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[[Category: Ip3 receptor]]
[[Category: Ip3 receptor]]
[[Category: Ip3 receptor suppressor domain]]
[[Category: Ip3 receptor suppressor domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 15:42:50 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:05:20 2008''

Revision as of 16:05, 28 July 2008

File:1xzz.png

Template:STRUCTURE 1xzz

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor

Template:ABSTRACT PUBMED 15664189

About this Structure

1XZZ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor., Bosanac I, Yamazaki H, Matsu-Ura T, Michikawa T, Mikoshiba K, Ikura M, Mol Cell. 2005 Jan 21;17(2):193-203. PMID:15664189

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