1r2b: Difference between revisions

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[[Image:1r2b.~~gif~~|left|200px]]

[[Image:1r2b.png|left|200px]]

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~~'''~~Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide~~'''~~

===Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide===

~~==Overview==~~

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~~BCL6 encodes a transcription factor that represses genes necessary for~~ the ~~terminal differentiation of lymphocytes within germinal centers, and~~ the ~~misregulated expression of this factor is strongly implicated in several types of B cell lymphoma. The homodimeric BTB domain of BCL6~~ (~~also known~~ as ~~the POZ domain~~) is ~~required for~~ the ~~repression activity of the protein and interacts directly with the SMRT and N~~-~~CoR corepressors that are found within large multiprotein histone deacetylase~~-containing complexes. We have identified a 17 residue fragment from SMRT that binds to the BCL6 BTB domain, and determined the crystal structure of the complex to 2.2 A. Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein.

The line below this paragraph, {{ABSTRACT_PUBMED_14690607}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14690607 is the PubMed ID number.

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==Disease==

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[[Category: Hdac complex]]

[[Category: Transcriptional repression]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 06~~:59:19 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:07:43 2008''

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-[[Image:1r2b.gif|left|200px]]
+{{Seed}}
+[[Image:1r2b.png|left|200px]]
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 {{STRUCTURE_1r2b|  PDB=1r2b  |  SCENE=  }}
-'''Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide'''
+===Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide===
-==Overview==
+<!--
-BCL6 encodes a transcription factor that represses genes necessary for the terminal differentiation of lymphocytes within germinal centers, and the misregulated expression of this factor is strongly implicated in several types of B cell lymphoma. The homodimeric BTB domain of BCL6 (also known as the POZ domain) is required for the repression activity of the protein and interacts directly with the SMRT and N-CoR corepressors that are found within large multiprotein histone deacetylase-containing complexes. We have identified a 17 residue fragment from SMRT that binds to the BCL6 BTB domain, and determined the crystal structure of the complex to 2.2 A. Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein.
+The line below this paragraph, {{ABSTRACT_PUBMED_14690607}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14690607 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14690607}}
 ==Disease==
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 [[Category: Hdac complex]]
 [[Category: Transcriptional repression]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 06:59:19 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:07:43 2008''