2gf5: Difference between revisions

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[[Image:2gf5.gif|left|200px]]
{{Seed}}
[[Image:2gf5.png|left|200px]]


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{{STRUCTURE_2gf5|  PDB=2gf5  |  SCENE=  }}  
{{STRUCTURE_2gf5|  PDB=2gf5  |  SCENE=  }}  


'''Structure of intact FADD (MORT1)'''
===Structure of intact FADD (MORT1)===




==Overview==
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The structure of FADD has been solved in solution, revealing that the death effector domain (DED) and death domain (DD) are aligned with one another in an orthogonal, tail-to-tail fashion. Mutagenesis of FADD and functional reconstitution with its binding partners define the interaction with the intracellular domain of CD95 and the prodomain of procaspase-8 and reveal a self-association surface necessary to form a productive complex with an activated "death receptor." The identification of a procaspase-specific binding surface on the FADD DED suggests a preferential interaction with one, but not both, of the DEDs of procaspase-8 in a perpendicular arrangement. FADD self-association is mediated by a "hydrophobic patch" in the vicinity of F25 in the DED. The structure of FADD and its functional characterization, therefore, illustrate the architecture of key components in the death-inducing signaling complex.
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{{ABSTRACT_PUBMED_16762833}}


==About this Structure==
==About this Structure==
2GF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF5 OCA].  
2GF5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GF5 OCA].  


==Reference==
==Reference==
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[[Category: Death effector domain]]
[[Category: Death effector domain]]
[[Category: Death-inducing signaling complex]]
[[Category: Death-inducing signaling complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:02:00 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:09:53 2008''

Revision as of 16:09, 28 July 2008

File:2gf5.png

Template:STRUCTURE 2gf5

Structure of intact FADD (MORT1)

Template:ABSTRACT PUBMED 16762833

About this Structure

2GF5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure of FADD and its mode of interaction with procaspase-8., Carrington PE, Sandu C, Wei Y, Hill JM, Morisawa G, Huang T, Gavathiotis E, Wei Y, Werner MH, Mol Cell. 2006 Jun 9;22(5):599-610. PMID:16762833

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