2z3r: Difference between revisions

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[[Image:2z3r.gif|left|200px]]
{{Seed}}
[[Image:2z3r.png|left|200px]]


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{{STRUCTURE_2z3r|  PDB=2z3r  |  SCENE=  }}  
{{STRUCTURE_2z3r|  PDB=2z3r  |  SCENE=  }}  


'''Crystal structure of the IL-15/IL-15Ra complex'''
===Crystal structure of the IL-15/IL-15Ra complex===




==Overview==
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Interleukin 15 (IL-15) and IL-2, which promote the survival of memory CD8(+) T cells and regulatory T cells, respectively, bind receptor complexes that share beta- and gamma-signaling subunits. Receptor specificity is provided by unique, nonsignaling alpha-subunits. Whereas IL-2 receptor-alpha (IL-2Ralpha) is expressed together in cis with the beta- and gamma-subunits on T cells and B cells, IL-15Ralpha is expressed in trans on antigen-presenting cells. Here we present a 1.85-A crystal structure of the human IL-15-IL-15Ralpha complex. The structure provides insight into the molecular basis of the specificity of cytokine recognition and emphasizes the importance of water in generating this very high-affinity complex. Despite very low IL-15-IL-2 sequence homology and distinct receptor architecture, the topologies of the IL-15-IL-15Ralpha and IL-2-IL-2Ralpha complexes are very similar. Our data raise the possibility that IL-2, like IL-15, might be capable of being presented in trans in the context of its unique receptor alpha-chain.
The line below this paragraph, {{ABSTRACT_PUBMED_17643103}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17643103 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17643103}}


==About this Structure==
==About this Structure==
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[[Category: Cytokine/cytokine receptor complex]]
[[Category: Cytokine/cytokine receptor complex]]
[[Category: Protein-protein complex]]
[[Category: Protein-protein complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 19:55:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:24:37 2008''

Revision as of 16:24, 28 July 2008

File:2z3r.png

Template:STRUCTURE 2z3r

Crystal structure of the IL-15/IL-15Ra complex

Template:ABSTRACT PUBMED 17643103

About this Structure

2Z3R is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans., Chirifu M, Hayashi C, Nakamura T, Toma S, Shuto T, Kai H, Yamagata Y, Davis SJ, Ikemizu S, Nat Immunol. 2007 Sep;8(9):1001-7. Epub 2007 Jul 22. PMID:17643103

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