2oqp: Difference between revisions

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[[Image:2oqp.jpg|left|200px]]
{{Seed}}
[[Image:2oqp.png|left|200px]]


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{{STRUCTURE_2oqp|  PDB=2oqp  |  SCENE=  }}  
{{STRUCTURE_2oqp|  PDB=2oqp  |  SCENE=  }}  


'''Solution structure of human interleukin-21'''
===Solution structure of human interleukin-21===




==Overview==
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The high resolution three-dimensional structure of human interleukin (hIL)-21 has been resolved by heteronuclear NMR spectroscopy. Overall, the hIL-21 structure is dominated by a well defined central four-helical bundle, arranged in an up-up-down-down topology, as observed for other cytokines. A segment of the hIL-21 molecule that includes the third helical segment, helix C, is observed to exist in two distinct and interchangeable states. In one conformer, the helix C segment is presented in a regular, alpha-helical conformation, whereas in the other conformer, this segment is largely disordered. A structure-based sequence alignment of hIL-21 with receptor complexes of the related cytokines, interleukin-2 and -4, implied that this particular segment is involved in receptor binding. An hIL-21 analog was designed to stabilize the region around helix C through the introduction of a segment grafted from hIL-4. This novel hIL-21 analog was demonstrated to exhibit a 10-fold increase in potency in a cellular assay.
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{{ABSTRACT_PUBMED_17565991}}


==About this Structure==
==About this Structure==
2OQP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQP OCA].  
2OQP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OQP OCA].  


==Reference==
==Reference==
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[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
[[Category: Multiple conformer]]
[[Category: Multiple conformer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 11:28:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:32:21 2008''
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